Literature summary extracted from

Samuel, M.; Samuel, E.; Villanueva, G.B.
The low pH stability of human coagulation factor XII (Hageman factor) is due to reversible conformational transitions (1994), Thromb. Res., 75, 259-268.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.38	additional information	factor XIIa undergoes large changes in secondary structures when exposed to low pH in the presence of dextran sulfate 500. The reaction of factor XII with dextran sulfate 500 at pH 5.3 results in loss of alpha-helical structure while at pH 8.3, in its formation. At pH 5.3 autoactivation is inhibitited. This may indicate that alpha-helical structure in factor XII plays an important role in the autoactivation mechanism	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.38	Homo sapiens	-	-	-

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Release 2023.1 (January 2023)